Holden option for Freedman
Bolton could hand a second league appearance of the season to Stuart Holden for the trip to Cardiff.
The US international has returned from a loan spell at Sheffield Wednesday where he made four appearances as he battles back to full fitness following a long-term injury.
Dougie Freedman could bring him into the squad in the continued absence of fellow midfielder Jay Spearing, who is still recovering from a broken toe.
He joins striker David Ngog on the sidelines, who will not feature again this season after dislocating his shoulder in the 3-2 defeat at Leicester.
Freedman has received a boost as defender David Wheater has returned to training after a calf injury.
Wanderers have won four of their last five and occupy the final play-off spot, but only Leeds and Bristol City have won fewer away games this season.