Robshaw rocked by injury blow
England captain Chris Robshaw admits he is "absolutely gutted" to miss Saturday's final Test against South Africa with a cracked thumb.
The 26-year-old was originally injured during the first Test and took a second blow to his right thumb in last weekend's loss in Johannesburg.
X-rays revealed a break and Robshaw said: "I'm absolutely gutted - it's a difficult way to end the season."
It is a further blow to England's hopes in the final Test after scrum-half Ben Youngs was earlier ruled out with a shoulder injury.
Thomas Waldrom and Danny Care could come into the side to face the Springboks in Port Elizabeth following their omission from the England line-up to take on South African Northern Barbarians tomorrow.
Hooker Dylan Hartley will captain the Test side in Robshaw's absence.
"Chris, as you would imagine, is devastated," said England head coach Stuart Lancaster.
"He has led us superbly in the last seven internationals and been one of our stand-out performers. But the medical advice is that he should not play and we have to trust that expert opinion."
England go into Saturday's match searching for their first win over South Africa since November 2006.