Saints chief bemoans triple injury blow
Nigel Adkins confirmed Frazer Richardson pulled a muscle against Fulham, while Nathaniel Clyne and Gaston Ramirez have dead legs.
The Southampton boss was forced to withdraw Richardson inside the opening 10 minutes of Sunday's 2-2 draw against the Cottagers at St Mary's while full-back Clyne and record signing Ramirez both missed out because of respective injury problems suffered ahead of the clash.
And, while Adkins bemoaned the loss of Richardson following an impressive start to the match, he also revealed both Clyne and Ramirez will not be fit enough to go on international duty with England's Under-21s and Uruguay respectively.
He told the club's website: "It looks like he (Frazer) has pulled his thigh muscle so we will get a scan on that and see the extent of the tear of the muscle.
"Nathaniel has a dead leg that he picked up at Everton and had to come off which he hasn't recovered from. I would suggest that as he hasn't played today he wont be fit to go away with England.
"Gaston has a similar thing with a dead leg that he picked up on Thursday but that was quite a serious one because the muscle swelled up as there was nowhere for the blood to go which led to a lot of pressure on his thigh. He had to have a couple of days in hospital to relief the pressure there so obviously he won't be joining up with Uruguay now in the international break."