Luis Suarez and Edinson Cavani were on target as Uruguay ensured they would finish at the top of Group A by beating 10-man Russia 3-0.
Top spot will be at stake in Samara on Monday afternoon when hosts Russia look to make it three wins from three against Uruguay.
Hosts Russia have one foot in the last-16 of the World Cup after eliminating Egypt with a 3-1 Group A win in St Petersburg.
Coach Stanislav Cherchesov is confident Russia have an adequate game plan to thwart Egypt's Mohamed Salah on Tuesday evening.
Hosts Russia got off to a flyer on Thursday and will be keen to build on their World Cup momentum on Tuesday against Egypt.
Nervy night in store for the hosts, but they should get result they need
Russia have appealed to UEFA in a bid to have their suspended point deduction and €120,000 fine overturned.
Andrey Arshavin has hit back at the criticism surrounding Russia's elimination from Euro 2012 and says it is not his side's concern.
The Russian Football Union has been fined by Uefa for crowd trouble in their 1-1 draw with Poland.
Russia manager Dick Advocaat has lamented his side's exit from Euro 2012 after last night's loss to Greece.
Russia goalkeeper Vyacheslav Malafeev says head coach Dick Advocaat deserves praise for their impressive start to Euro 2012.
Russia coach Dick Advocaat has tried to manage expectations ahead of tonight's Group A clash with co-hosts Poland in Warsaw.
The Russian FA has urged its supporters to behave after they threw fireworks and displayed illicit banners during Russia's first game.
Russia coach Dick Advocaat believes his side still have room for improvement following their 4-1 win over Czech Republic.
Russia coach Dick Advocaat insists his side can go all the way at Euro 2012, if they believe in themselves.
Russia goalkeeper Vyacheslav Malafeev admits there are nerves in the camp ahead of Friday's Euro 2012 clash against Czech Republic.
Russia goalkeeper Igor Akinfeev is still struggling with a knee injury ahead of his side's opening match on Friday.
Russia manager Dick Advocaat has played down his sides Euro 2012 chances despite an impressive recent win over Italy.