The Dons faithful have had to endure a difficult season and are currently 11 games without a win with some of McGhee's squad failing to live up to previous standards.
The former Wolves boss says he has drawn up a list of 100 potential replacements for some of his sub-standard players, including Mark Kerr, Charlie Mulgrew and Gary McDonald, who all look set to leave the club at the end of the season.
McGhee says Aberdeen fans can expect a whole host of comings and goings this summer.
"The changes will be comprehensive because it is clear that is what is needed," he insisted. "There will be a natural cull of those who'll be out of contract and others who will be moved on. So, I'm anticipating a lot of movement and a great deal of work has been going on since last summer to allow that to happen."