Midfielder Craig Stanley will have to wait for his debut after suffering a broken leg in pre-season.
Goalkeeper Ross Worner is also likely to miss a number of months after being scheduled for a back operation next week.
New defender Guy Branston is unlikely to make his first appearance just yet after suffering an injury in a recent friendly.
Holdsworth’s other remaining absentee is striker Danny Hylton as he serves the first of an eight-match ban after being fined for racial abuse.
However, other new signings Oli Lancashire, Craig Reid and Anthony Tonkin and returning Hull loanee Sonny Bradley are expected to start.
Neil Lennon was sent to the stand as his Hibernian team let slip a two-goal lead at Kilmarnock.
Bristol City boss Lee Johnson turned up the tension ahead of Sunday's Severnside derby by highlighting a lack of atmosphere at the Cardiff City Stadium.
Liverpool forward Mohamed Salah has set his team a clear target for the season: qualification for next year's Champions League.