The Gunners have sold all 60,000 tickets available for the game at the Emirates Stadium, but access to the stadium for both supporters and the club's 1,000 matchday employees could be restricted if the planned strikes go ahead.
Drivers have planned a 24-hour walkout on Boxing Day and on three other days over the next month, and the club said in a statement on their website: "We would like to make all supporters aware of the situation surrounding our proposed home match against Wolves on Monday 26th December.
"The club is fully aware of the proposed industrial action on London Underground on Monday 26th December.
"We are closely monitoring the situation, together with all the relevant agencies, including the Metropolitan Police, Transport for London, London Underground, the FA Premier League, Wolverhampton Wanderers FC and Islington Council.
"The paramount concern to Arsenal Football Club is the duty of care we have towards the Arsenal supporters, Wolverhampton Wanderers supporters, matchday employees and indeed everyone who is planning to attend this match. Any decisions or developments regarding this match will be immediately communicated on Arsenal.com."