Gunners skipper Fabregas made his return from yet another hamstring problem against Manchester United two weeks ago and has now been declared fully fit for the visit of the Blues.
Fabregas is likely to be joined in the starting line-up by Van Persie, who has been used sparingly after his return from an ankle injury.
The Dutch striker could come in for Marouane Chamakh, who Wenger has revealed is beginning to feel the strain of high intensity English football and could start from the bench against Chelsea.
Elsewhere, Wenger has a decision to make over whether he keeps faith with youngster Wojciech Szczesny in goal or recalls the fully fit Lukasz Fabianski between the sticks.
Manuel Almunia, Thomas Vermaelen and Kieran Gibbs are all still unavailable.