Mellis returned from a seven-game lay-off with a dead leg as a substitute in last week's derby win over Leeds and could step in for Jim O'Brien, who was stretchered off in the same game after suffering a similar injury and is definitely out.
New manager David Flitcroft, handed the job on a permanent basis on Sunday, has no other new injury or suspension problems and is unlikely to make too many, if any, changes after steering the Tykes to back-to-back victories.
Defender Scott Wiseman was left out of the squad last week after his scheduled move to Blackpool was placed on hold and it remains to be seen whether he is included.
Bobby Hassell and Stephen Foster are pushing for recalls, while teenagers Danny Rose and Reuben Noble-Lazarus are expected to start on the bench again.
Barnsley last week