Craig Dawson's return to parent club West Brom at the end of his loan stint creates a vacancy alongside Zat Knight at the heart of defence, with Tim Ream and Matt Mills also in contention.
But Wheater appears favourite to get the nod from boss Dougie Freedman, having recovered from a calf strain that has hindered him in recent weeks.
The 26-year-old has three substitute appearances to his name since returning from a long-term knee injury against Hull at the end of February, while Ream and Mills have featured even more sparingly.
USA international Ream last played in the 2-1 defeat at Watford, three weeks before Wheater's comeback, while a hamstring complaint has played its part in Mills only featuring once since the turn of the year.
David Ngog (shoulder), Jay Spearing (toe) and Mark Davies (knee) remain on the sidelines.
Bolton last week