The 25-year-old looks set to join the newly promoted side after the completion of a medical and the relevant international clearance paperwork.
Brighton are believed to be paying an initial £13.5m, rising to £16m, which would break their transfer record for a third time this summer, following deals for Australian goalkeeper Mathew Ryan and Dutch midfielder Davy Propper on Monday.
The medical is expected to take place in the next 24 hours and the deal should be confirmed on completion by the weekend and boss Chris Hughton says he’s excited at the prospect of working with Izquierdo.
"Jose is someone we have been aware of for sometime and has been one of the standout players in the Belgian league over the past three years," the Seagulls boss said.
"He's been an exciting player for Club Brugge and in the season he helped the club win the title in 2015/16, he was also Belgium's Player of the Year."