The 25-year-old has endured a torrid time since making his Bundesliga debut on the opening day of the 2013/14 season.
Knee problems have been the issues in the past, with the German undergoing two previous operations.
However, Durm is now set to go under the knife for a third time, with a troublesome hip injury being the root of the problem.
Dortmund boss Peter Bosz now has a growing injury list as Marc Bartra (adductor), Raphael Guerreiro, Marco Reus, Sebastian Rode, Marcel Schmelzer (all ankle) and Andre Schurrle (muscular) are also sidelined.
Watford boss Javi Gracia does not think Abdoulaye Doucoure's form will be affected by his omission from France's latest squad.