The American international defender had played every minute of the season until being forced off in the first half of October's 2-2 draw against Borussia Dortmund and was expected to be out until the new year.
However, having had an operation to repair torn cartilage in his knee, Chandler has made a speedy recovery and could be back before the winter break.
The 27-year-old is back in training and although Saturday's visit of Bayern Munich is likely to be too early, there will be other opportunities for him to play.
Die Adler are set to play Hamburg and Schalke ahead of the mid-season hiatus, before rounding off their year against Heidenheim in the DFB-Pokal.
Frankfurt are currently eighth in the Bundesliga table, just two points shy of Borussia Monchengladbach, who occupy the final Champions League spot.