The highly-rated 22-year-old Switzerland international central defender has been linked with a host of clubs this month having enjoyed an impressive spell in his homeland with Basel since 2015.
Premier League trio Liverpool, West Ham and Southampton had all been named as potential suitors, but reports claim Dortmund are set to secure Akanji’s services despite the two clubs being around 5million euros apart in their respective valuations earlier in the week.
No fee has been mentioned, but it is expected that a deal will go through in the coming days.
Colchester will hand late fitness tests to Ryan Jackson and Brandon Comley prior to their clash with Yeovil.
Arsenal secured their place in the quarter-finals of the Europa League following their 3-1 defeat of AC Milan at the Emirates Stadium on Thursday.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Ipswich striker Joe Garner will not play again this season after it emerged he suffered a fractured skull against Sheffield United last week.