Dortmund went into Wednesday night's Champions League clash against Tottenham with a host of injury problems, and Gotze was added to it after the 3-1 defeat.
Tottenham defender Jan Vertonghen was sent off late in the game after he swung an arm into the face of Gotze, who now needs a trip to the dentist.
Dortmund manager Peter Bosz reported Gotze as having sustained an injury to his teeth, handing the already-depleted German side yet another fitness concern.
"He's got problems with his teeth and he's got to go to the doctor," Bosz said. "It doesn't look that good with his teeth so obviously that hurts us as well."
Harry Kane's goals had earlier inspired Spurs to a 3-1 win. Dortmund's Andriy Yarmolenko had cancelled out Son Heung-min's early strike with a stunning long-range effort but the contest belonged to Kane thereafter.