The Clarets were outclassed 3-1 at St Mary's in October, a result that has contributed to their torrid away form this season, with just a single point picked up on the road.
However, they have been excellent at Turf Moor, winning seven games to lift themselves up to 12th in the Premier League.
Saturday provides them with the chance to further boost their survival hopes when they host Claude Puel's men, who will arrive in Lancashire having lost their last three in the league.
After such a disappointing showing on the south coast, Lowton believes the return fixture provides his Burnley side with a chance to get their own back.
"We've already played them once and didn't give a good account of ourselves," he told the club's official website. "They had a 15-minute period where they scored a couple of goals and took the game away from us.
"In the earlier part of the season away from home we weren't doing what we normally do.
"I'm sure they'll know as much as we do that we're a different team at home and I'm sure they're not looking forward to coming to Turf Moor."
Lowton added: "We'll go out there and try to make sure that we get in their faces and take our chances like we have done in the last few home games."