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Tottenham Hotspur coach Mauricio Pochettino will be without centre-back Jan Vertonghen for Saturday's clash with Sheffield United.
Alex Oxlade-Chamberlain is pushing for inclusion in Sunday’s crucial clash with Manchester City, but it would be a huge call for Jurgen Klopp.
Nuno Espirito Santo could well make a number of changes to his starting line-up for Wolves' Premier League clash with Aston Villa on Sunday.
Burnley and West Ham United will both be looking to get back to winning ways when they meet at Turf Moor on Saturday.
High-flying Leicester have no fresh injury concerns as they get set to welcome struggling Arsenal to King Power Stadium for a top-four showdown.
Scott McTominay is a doubt for Manchester United, who are without suspended captain Ashley Young, for the visit of Brighton and Hove Albion on Sunday.
Newcastle will once again be without Fabian Schar and Matt Ritchie for Saturday's Premier League clash with Bournemouth at St James' Park.
Chelsea look set to welcome back N’Golo Kante into the starting line-up as they prepare to host Crystal Palace on Saturday.
Southampton and Everton play out an early six-pointer on Saturday with both managers in serious danger of getting the boot.
The Premier League’s bottom two go head-to-head in a massive game for both sides on Friday night.
Troy Deeney is set to return to the Watford squad to face Norwich, who have midfielder Mario Vrancic available for the first time since August.
Manchester United will be without central defender Victor Lindelof because of a back problem for the Europa League Group L clash against Partizan Belgrade.
Tottenham will take a huge step towards Champions League qualification if they can secure all three points at Red Star Belgrade on Wednesday.
Manchester City could book their place in the Champions League knockout stages if they maintain their 100 per cent record against Atalanta on Wednesday.
Chelsea have been boosted by the news that key midfielder N'Golo Kante has recovered from injury and is fit to face Ajax on Tuesday night.
Jurgen Klopp has reported no fresh injury concerns ahead of the clash with Genk but looks set to freshen up his side for the Champions League showdown.
Everton will monitor the fitness of defender Yerry Mina right up to kick-off but Marco Silva is reluctant to rule him out of Sunday's clash with Tottenham.
Crystal Palace are likely to be without winger Andros Townsend against in-form Leicester on Sunday.
Under-fire skipper Granit Xhaka will not play in Arsenal’s game at home to Wolves on Saturday, according to manager Unai Emery.
Aston Villa boss Dean Smith remains hopeful Jack Grealish will be fit for Saturday's home clash with Liverpool.
Sheffield United forward Lys Mousset is pushing for a starting spot ahead of the visit of Burnley on Saturday.