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Newcastle United are dealing with a handful of injuries as they prepare to welcome Brighton to St James’ Park on Saturday.
Southampton will be forced to do without winger Moussa Djenepo for Friday night's Premier League match against Bournemouth.
Nuno Espirito Santo admits he will have to rotate his Wolves side for Thursday's Europa League clash with Braga at Molineux.
Manchester United will hand a start to Mason Greenwood on Thursday night as Ole Gunnar Solskjaer makes changes for the clash with Astana.
Unai Emery says Mesut Ozil will play no part against Eintracht Frankfurt on Thursday night and will be rested ahead of the weekend.
Tottenham will be without a number of key players as they look to banish the memory of last season's Champions League final defeat.
Pep Guardiola is backing Fernandinho to step up to the plate as Manchester City's injury problems in central defence go from bad to worse.
Chelsea boss Frank Lampard will have to do without defender Antonio Rudiger as they prepare to welcome Valencia to Stamford Bridge on Tuesday night.
Divock Origi has not been included in Liverpool's travelling squad for their Champions League opener against Napoli as he struggles with an ankle injury.
Aston Villa will look to climb out of the relegation zone when they welcome West Ham United to Villa Park on Monday evening.
Bournemouth midfielder Lewis Cook could be in line for his first appearance since December when Everton visit on Sunday.
Quique Sanchez Flores gets his second managerial stint at Watford underway on Sunday as Arsenal make the trip to Vicarage Road.
Norwich could be without as many as 11 first-team stars for Saturday's visit of Manchester City in the Premier League.
Liverpool bid to maintain their perfect start to the Premier League season when Newcastle United visit Anfield on Saturday.
Wolves will be without suspended Wily Boly for the visit of Chelsea, while Antonio Rudiger could make his first appearance of the season for the visitors.
Sheffield United will attempt to build on a positive start to the season when they host Southampton on Saturday.
Tottenham could be boosted by the return of four players for Saturday's London derby with Crystal Palace in the Premier League.
Manchester United will be without Paul Pogba and Anthony Martial for Saturday's Premier League visit of Leicester, who boast a near clean bill of health.
Brighton could have defender Ezequiel Schelotto back from a knee injury for the visit of Burnley, who expect to have Dwight McNeil and Ashley Barnes fit.
Mesut Ozil and Dele Alli could both feature for the first time this season as both Arsenal and Spurs gear up for the first North London derby of 2019-20.
Everton will be without Jean-Philippe Gbamin for the visit of Wolves on Sunday.