Jol rotated some of his key men for Thursday’s Europa League draw with FC Twente and both Duff and Zamora started on the bench against the Dutch outfit.
The pair joined the action in the second half at Craven Cottage but should be fresh and are set to start against high-flying City.
Andrew Johnson was on target against Twente so he will hope to keep his place in the side, but deadline-day signing Bryan Ruiz is available after sitting out the Europa League game as he was ineligible.
Zdenek Grygera made his debut on Thursday and could also retain his place in defence as the Cottagers hope to dent City’s title ambitions.
England manager Gareth Southgate has claimed that the country needs to boot racism out of its own football before criticising World Cup hosts Russia.
Newcastle have been linked with a shock move for former Sunderland goalkeeper Simon Mignolet during the summer.