Fredericks was rested for the 1-1 draw at Bristol City on Wednesday and his replacement Cyrus Christie impressed on his debut.
Fulham boss Slavisa Jokanovic has a full squad to choose from for the showdown between fifth and top.
But Jokanovic might decide to rotate as the Cottagers will play their second game in less than 72 hours, with Tomas Kalas and Floyd Ayite among those hoping for possible recalls.
Wolves will be without their influential midfielder Ruben Neves.
The Portuguese collected his 10th yellow card of the season against Norwich in midweek and must serve a two-game suspension.
Romain Saiss could therefore return to the starting line-up after being on the bench for the last two games following injury.
Benik Afobe and Leo Bonatini are challenging for places in attack as Wolves seek to get back to winning ways following draws with Preston and Norwich.
Pedro stepped off the bench to send Chelsea into the FA Cup semi-finals after they beat Leicester 2-1 at the King Power Stadium on Sunday evening.
RB Leipzig came from behind at the Red Bull Arena to end a run of four winless games and defeat Bundesliga leaders Bayern Munich 2-1 on Sunday.