The teams head into the clash at Ewood Park with contrasting fortunes as Rovers continue their battle against the drop while North End are challenging for a play-off spot.
The hosts are currently sitting 21st in the Championship although they could end up in the relegation zone before Saturday's match if Bristol City, who are in 22nd, get at least a point at home to Huddersfield on Friday night.
Eighth-placed Preston are looking to make a late charge for the play-offs and will hope to build on the 3-0 victory over Reading last time out.
Horgan, who arrived at Deepdale in January from Dundalk, is hopeful his side can get the victory needed to boost their top-six hopes.
"Any derby that I’ve played in, it always has that bit of unexpectedness and anything can happen," he told the club's website. "Blackburn are having a tough time at the minute but got a good result against Fulham on Tuesday, so they’ll be right up for it.
"There’s a new manager with new ideas, so that’ll help them, but hopefully we can play the game as it is, as opposed to getting too soaked up in the derby atmosphere and pick up the three points that we need."