McCleary sustained injury in last week’s home defeat to Sheffield United and it has been confirmed as a broken ankle.
Omar Richards and Yann Kermogant are still out due to respective calf injuries, although the latter is closing in on his return.
Defenders Paul McShane and Tommy Elphick, plus forward Joseph Mendes and winger Callum Harriott all remain sidelined.
Leeds defender Liam Cooper is an injury doubt after sustaining a dead leg in the midweek defeat to Wolves and will be monitored.
Forward Kemar Roofe is also doubtful after missing the last three games due to a calf injury.
Goalkeeper Bailey Farrell-Peacock made a rare start in midweek and boss Paul Heckingbottom must decide between him, Felix Wiedwald and Andy Lonergan, who is hoping to be fit after a sore neck.
Defenders Conor Shaughnessy and Luke Ayling (both ankle) remain unavailable as Leeds bid to avoid a third straight league defeat.
Everton target Jack Wilshere has sparked a scramble for his signature after confirming he is leaving Arsenal this summer.
Tottenham's hopes of landing Wilfried Zaha have been hit by the news Crystal Palace have offered him a bumper new deal to stay.
Ryan Giggs says Gareth Bale would be the perfect fit for Manchester United but has doubts over whether he will leave Real Madrid.
Manchester City's attempts to sign Riyad Mahrez could be in doubt again as reports claim Leicester only want a straight cash deal.
Eden Hazard has suggested his future at Chelsea hinges on Antonio Conte and says Real Madrid know what they need to do to sign him.