Friend has been sidelined since suffering a calf muscle injury in the 1-0 victory over Accrington in the last round of the domestic cup competition, but he has now fully recovered.
Gaston Ramirez could also be given his first start since January 2 after earning some game time from the bench in last weekend’s goalless draw with Everton.
However, summer signing Antonio Barragan remains out with a hamstring problem and January arrival Adlene Guedioura is cup-tied after featuring for Watford in the FA Cup.
Antonio Conte took the opportunity to compliment a rare talent after Lionel Messi masterminded Barcelona's Champions League defeat of Chelsea.
Wigan boss Paul Cook is happy to be heading into their FA Cup quarter-final with Southampton on the back of a morale-boosting league win.
Arsene Wenger has called on his Arsenal side to put on the sort of displays that will have stay-away fans returning to the Emirates Stadium.
Michael Jacobs struck in stoppage time as Wigan got their League One promotion bid back on track with a 1-0 win at Bradford.
Lionel Messi punished error-prone Chelsea as Barcelona advanced to the Champions League quarter-finals with a 3-0 win at the Nou Camp.
AC Milan boss Gennaro Gattuso believes Jack Wilshere would grace any league in world football.