Ayling sustained the injury in the 0-0 draw with Nottingham Forest on New Year’s Day and the 26-year-old has now announced via Twitter that his season is over.
He tweeted: “Not what any of us wanted… ankle wasn’t as good as we all first thought… now time to rest, recover and hopefully get back sooner then [sic] they think.. thank you all for your messages means a lot.”
Leeds may opt to bring in a new full-back during the January transfer window to replace Ayling, who put pen-to-paper on a new five-year deal with the club last summer.
Javi Gracia said it was always going to be an uphill battle for Watford after conceding so early against Liverpool on Saturday.
Schalke 04 boss Dominico Tedesco paid tribute to goalkeeper Ralf Fahrmann after his 76th-minute penalty save proved crucial in a 1-0 win over Wolfsburg.
Mattia De Sciglio stunned that Juventus were shocked to be held to a goalless draw with SPAL on Saturday.
Sunderland have suspended midfielder Darron Gibson with immediate effect after he was charged with drink driving.
Jose Mourinho's recent bad frame of mind was still present despite Manchester United beating Brighton 2-0 at Old Trafford on Saturday, a result that puts them into the last four of the FA Cup.
Mohamed Salah continued his astounding goalscoring form on Saturday, hitting four goals as Liverpool thrashed Watford 5-0 at Anfield.