The Tottenham midfielder, on loan until the end of the season, stepped off the substitutes’ bench for the last half an hour in the midweek draw at MK Dons, but may replace Chris Sedgwick in the starting line-up.
Megson has no new injury or suspension problems and is unlikely to make too many, if any, other changes to his side.
Miguel Llera is likely to continue at centre-half in the continued absence of Rob Jones, who has missed the last three games due to an ankle problem, while another defender, Julian Bennett, is still out with a shoulder injury.
Mike Jones, a recent signing from Bury, is hoping to be included in the squad after being omitted in midweek, while fellow winger Jermaine Johnson is pushing for a recall to the starting line-up.
Wednesday will start the game in third place, level on points with Huddersfield, who occupy the second automatic promotion spot.
Grimsby are open to talking to Sol Campbell about their vacant managerial position - and the former England defender wants to make it happen.
Grimsby are open to talking to Sol Campbell about their vacant managerial position.