The arch rivals have an excellent record at the Stadium of Light, just one defeat coming back in 2008, but Mignolet believes that is about to change.
The Belgium ace believes the rejigging of the stadium will help as away fans have been moved from behind the goal to up in the Gods in the north west corner, meaning home fans surround the pitch.
“It will be tight and the supporters will be behind us so hopefully we can get a good result again,” Mignolet told the club’s website.
“In the home games we’ve played we’ve felt the difference in comparison with last season. At both ends the home fans are behind us now and that can only help us in getting more points at home.”
Captain Graeme Shinnie scored the only goal of the game as Aberdeen laboured to end a run of four league games without a win, beating Dundee 1-0.
Boss Danny Cowley felt Lee Frecklington's moment of brilliance helped decide the Lincolnshire derby in Lincoln's favour as they beat Grimsby 3-1.
Millwall manager Neil Harris was delighted with his side as they comfortably won 2-0 at Barnsley.
A three-goal burst inside eight first-half minutes ensured Lincoln secured derby bragging rights with a 3-1 victory over struggling Grimsby.
Millwall's unbeaten run of games stretched to eight in the Sky Bet Championship as they comfortably defeated Barnsley 2-0 at Oakwell.