Following Thursday’s 1-1 draw against West Ham, Mauricio Pochettino rang the changes, making eight in all as Victor Wanyama made his first start since August, while Fernando Llorente partnered Harry Kane in attack.
The Dons themselves made four alterations and having set themselves out to defend, it soon became a game of attack against defence.
However, despite chances for most notably Kane and Erik Lamela, visiting goalkeeper George Long was rarely troubled by the home side and it was the League One outfit who came closest before the break when Jimmy Abdou hit the underside of the crossbar.
The Dons came out with renewed vigour in the second stanza and Andy Barcham should have done more when he found space on the right, only to miscue his cross to Lyle Taylor.
Darius Charles then had a header tipped over by Michel Vorm but Spurs soon started to reassert themselves and substitute Son Heung-min provided plenty of energy following his arrival.
It paid off as well and it was that man Kane who opened the scoring on 63 minutes, firing home from close range following nice work from Moussa Sissoko and Kieran Trippier.
Two minutes later, Kane grabbed a second, showing his poacher’s instinct to pounce on Kyle Walker-Peters’ deflected effort and finished well to take him past Teddy Sheringham on 125 goals to become the club’s ninth highest scorer.
Spurs kept coming and it was Jan Vertonghen with the third, grabbing his first goal since 2013 with a stunning effort, which caught a slight deflection, from 30 yards.
That was it for the scoring action and it will be Spurs who take their place in Monday’s draw.
England manager Gareth Southgate has claimed that the country needs to boot racism out of its own football before criticising World Cup hosts Russia.
Newcastle have been linked with a shock move for former Sunderland goalkeeper Simon Mignolet during the summer.