The Honda engines have struggled with performance and reliability issues since linking up with McLaren three years ago and the Woking-based team has confirmed it has now ended their relationship.
"For a combination of reasons our partnership has not flourished as any of us would have wished," said McLaren boss Zak Brown. "It is certainly not for the want of effort on the part of either Honda or McLaren, but the time has come to move ahead in different directions."
McLaren has not managed a single podium finish in the three years it has been partnered by Honda, with driver Fernando Alonso indicating he could leave the team if the issues were not resolved.
Alonso is now expected to agree a new deal with McLaren to remain for the 2018 season.
However, Honda will remain in Formula 1 and will move to Toro Rosso, who used Renault engines this season.