The American international forward feels Martin Jol's Cottagers are due a first three-point haul of the season and feels it will be the ideal time to secure it against their London rivals at Craven Cottage.
And, while Dempsey is expecting a tough encounter against Neil Warnock's impressive-looking squad, he is confident of a victory.
"It would be a good time to put down that first win especially as this is a game that everyone is looking forward too," he told fulhamfc.com.
"Fans always want to do well in these derby games and with it being the first between the two clubs in a little while there's even more interest as a result.
"To be honest, it doesn't matter who that first win comes against as long as it happens at some point.
"QPR have started the season well and will be looking to come to Craven Cottage in the hope of adding to that. But we're confident that we can get the result that we need."
Fulham last week