The 34-year-old carded a two-over par 74 on day one but began his second round with a birdie at the Charlotte course.
However things took a turn for the worse on the back nine for the 14-time major winner with three successive bogeys from the 10th, followed by two double bogeys at the 14th and 15th to finish nine-over par for his 36 holes.
The North Carolina tournament is just Woods' second event back on the US Tour following five months away from the game caused by his car crash in Florida and subsequent revelations about his private life.
The world number one finished fourth at the recent Masters and looked to have lost little of his fighting qualities and skill during his months away from the sport.
But Friday's debacle on the back nine was some of the worst golf he has played as a professional and the Florida resident was at a loss to explain the way he played, saying: "Whatever it was, it wasn't good enough."
American Billy Mayfair leads after two rounds on -8, with Argentina's Angel Cabrera one shot back in second.
Masters champion Phil Mickelson has moved ominously up the leaderboard and sits in a group of four players on six-under par, ready to strike at the weekend.
Padraig Harrington leads the European challenge on level par, while Masters runner-up Lee Westwood currently sits on +1 after two rounds.