Wyke, on loan from Middlesbrough, was forced off in the second half of Saturday’s 2-1 win at Scunthorpe and replaced by Steve Howard.
Howard is likely to continue alongside James Poole if Wyke fails to make it.
Otherwise, manager John Hughes could name an unchanged starting line-up for the seventh game running as Pools look to extend their unbeaten league run to seven matches.
Midfielder Antony Sweeney is still struggling with a knee injury and teenage defender Jordan Richards has been ruled out for the rest of the season after undergoing surgery on his knee cartilage problem.
Pools are chasing three straight league wins for the first time since September 2011 as they continue their bid to escape relegation.
Malcom has admitted the time is right for him to leave Bordeaux and is dreaming of a move to German giants Bayern Munich.
Jurgen Locadia is eyeing a first Premier League start for Brighton and is confident they can avoid relegation this season.