The Giants are preparing to play their first top-flight game in 45 years and they will travel to Selhurst Park on Saturday afternoon.
Smith fractured his foot in the Championship play-off final in May but he is ready to play despite missing the majority of pre-season.
He will captain the team after Mark Hudson retired this week, but Wagner does face selection headaches.
Martin Cranie (hip) and Jon Gorenc Stankovic (knee) remain long-term absentees but Jonathan Hogg and Nahki Wells are both struggling with ankle injuries.
Provisional squad: Lossl, Coleman, Schofield, Smith, Malone, Lowe, Jorgensen, Schindler, Hefele, Whitehead, Scannell, Billing, Mooy, Van la Parra, Lolley, Williams, Ince, Palmer, Kachunga, Depoitre, Quaner, Mounie.