The Republic of Ireland international received his 10th yellow card of the season in Saturday's win at Huddersfield and will sit out a two-game ban.
Manager Steve Bruce is hoping fellow midfielder Stephen Quinn can shake off the knee injury that kept him out at the weekend to cover for Meyler, but he too remains doubtful so Tom Cairney could come into contention.
Striker Gedo is pushing for a recall and Bruce must decide whether to stick with the in-form George Boyd up front alongside Jay Simpson or include the Egypt international in his starting line-up.
Defender Abdoulaye Faye will continue in the absence of Paul McShane, out for the rest of the season with ankle ligament damage, while Corry Evans, Leroy Rosenior and Ahmed Fahti are all hoping to be involved.
The Tigers, in second, are looking to extend their four-point advantage over third-placed Watford.