Niasse joined the Tigers on loan in January from Everton for the remainder of the season but he is ineligible to play against his parent club when the teams meet at Goodison Park.
The Senegal international has had a massive impact since arriving at the KCOM Stadium, having scored three times from eight Premier League games, and his presence will be missed.
Head coach Marco Silva will also be without Evandro, who joined permanently from Porto in January, as the midfielder continues to struggle with a calf issue that has kept him out of the last three matches.
Norwegian Markus Henriksen is back in training after a shoulder injury but is unlikely to feature whilst Michael Dawson, Dieumerci Mbokani and Ryan Mason remain on the sidelines.
Provisional squad: Jakupovic, Marshall, Elabdellaoui, Ranocchia, Maguire, Davies, Robertson, N'Diaye, Huddlestone, Clucas, Markovic, Elmohamady, Grosicki, Meyler, Hernandez, Diomande, Maloney, Tymon.