Before taking over the side last summer, the 44-year-old had a tumour removed from his parotid gland but suffered a relapse in December, causing him to miss a large chunk of the current campaign.
Cruyff himself had a number of health issues during his time in charge at the Nou Camp and was forced to undergo a double heart bypass in 1991, after decades of heavy smoking.
The Dutchman admits he found it difficult when he returned to work following his health problems and believes it would be best for both Vilanova and the club if the boss took time out from the game to help with his health.
"In his condition it's not very advisable to continue as a coach," he told Catalunya Radio. "I had a heart operation myself... can you be in charge of Barca if you aren't 100 per cent?"
"I'd tell Tito to look after himself. He's not as strong and experienced as Pep Guardiola. He has a massive problem in the form of his illness and his health comes first."