Les Rouges et Blancs made it six wins in a row in all competitions as goals from Boschilia, Guido Carillo and a brace from Valere Germain saw them cruise past Rudi Garcia’s side.
The result moved them to the top of the table, with rivals Nice and Paris Saint-Germain both due to play on Sunday.
Monaco have impressed in recent years, with boss Leonardo Jardim earning widespread praise for his ability to mould his young squad.
It appears the Portuguese has found the perfect blend this season and versatile midfielder Fabinho believes they are ready to push for the club’s first title since 1999-00.
“We’re not going to put limits on ourselves,” Fabinho said. “Go for the title? I think so, yes.
“It’s us against Paris Saint-Germain and Nice now, and we’re going to try and keep going like that.”
Port Vale manager Neil Aspin praised his side's 'fighting spirit' after they came back from two goals down to draw 2-2 with Stevenage at Vale Park.
Garry Monk had every reason to have a wide smile on his face after guiding Birmingham to a vital 3-0 Championship home win over below-par Hull.
Lee Johnson was delighted for Milan Djuric after the striker's 64th minute goal boosted Bristol City's Sky Bet Championship play-off bid.
Sheffield United manager Chris Wilder was left frustrated with his team's quality in the final third after they drew 0-0 against Nottingham Forest.
Mark Robins praised his players resilience as Coventry's game management counted in a hard-fought victory at Crewe.
Gary Bowyer admitted he was glad to see the back of Southend goalkeeper Mark Oxley after he frustrated Blackpool once more.
Plymouth playmaker Graham Carey converted an 85th-minute penalty as Argyle soared back into the League One play-off race with a 3-2 win over Westcountry rivals
James Maddison's 14th goal of the season helped Norwich get back to winnings way with a well deserved 3-2 victory that piled the pressure on Jaap Stam's Reading