The Ligue 1 champions made it through to the semi-finals of the competition last season, however, they have been unable to perform as consistently in 2017-18.
Monaco head into Wednesday's final Group G game against Porto sitting bottom of the pool and without any possibility of claiming a place in the Europa League.
Jardim believes it is the perfect opportunity to shuffle his starting lineup and feels his younger players will benefit from the experience of playing in a European clash.
"We will make five changes to our starting line-up and this fixture will give some of our young players a great opportunity to face a good team in this tournament," Jardim said.
"Looking ahead, this European experience will help the guys in terms of giving them a feel for what nights like this are all about."