The Brazilian was expected to be one of the first names on the team sheet for PSG's latest league game.
Unai Emery's side are cruising to the Ligue 1 title, holding an eight-point lead with a game in hand.
Neymar has helped the club progress in the Coupe de la Ligue and Coupe de France in the last week but he has now suffered a rib problem.
PSG have decided to rest the former Barcelona star, while midfielder Javier Pastore is also out with an injury.
Neymar is currently suffering with costal cartilage pain and Emery will be hoping his side can battle on without him this weekend.