Wyke was shown a straight red card in the Bantams’ defeat at Plymouth at the end of last month and has yet to start his three-game ban.
Boss Simon Grayson could recall long-term absentees Alex Jones (ankle) andOmari Patrick (knee) to the squad for his first home game in charge.
City, whohave not played a match at Valley Parade since February 10 due to other teams’ involvement in the FA Cup and bad weather, are still withoutJake Reeves (groin) and Ryan McGowan (knee).
Wigan boss Paul Cook has no new injuries and a full-strength squad to choose from.
Latics face Southampton in the quarter-finals of the FA Cup on Sunday, but Cook confirmed he will be fielding his strongest side.
Experienced trio Alex Bruce, Gary Roberts and James Vaughan are pushing for recalls to the starting line-up.
Wigan are in third place, eight points behind leaders Blackburn with four games in hand.
Rangers manager Steven Gerrard is weighing up a move for Liverpool full-back Jon Flanagan, reports claim.
Scottish champions Celtic are reportedly ready to offer full-back Calvin Miller a new deal before sending him out on loan.
Everton target Jack Wilshere has sparked a scramble for his signature after confirming he is leaving Arsenal this summer.
Tottenham's hopes of landing Wilfried Zaha have been hit by the news Crystal Palace have offered him a bumper new deal to stay.
Ryan Giggs says Gareth Bale would be the perfect fit for Manchester United but has doubts over whether he will leave Real Madrid.
Manchester City's attempts to sign Riyad Mahrez could be in doubt again as reports claim Leicester only want a straight cash deal.