Clarke was ineligible to play against his parent club Oldham in Saturday’s 2-2 draw at Gigg Lane.
Elsewhere, manager Ryan Lowe has no fresh injury concerns as he looks to haul his side off the bottom of the table.
Craig Jones (thigh), Jermaine Beckford (knee) and Eoghan O’Connell (ligaments) are all sidelined.
Peterborough defender Ryan Tafazolli is set to make his return from injury.
Tafazolli has missed the last two matches after suffering a hamstring problem but is set feature for Posh.
Midfielder Anthony Grant should return to contention following a knock.
Defender Alex Penny (shoulder) and midfielder Gwion Edwards (ankle) are both long-term absentees.
Morecambe have no fresh injury concerns ahead of Tuesday's Sky Bet League Two home clash with Colchester.