The Dutch forward is still struggling with the knee injury he sustained against AFC Wimbledon a fortnight ago.
Winger Hildeberto Pereira will come back into contention after completing a one-match ban following his red card against Gillingham.
DefenderLeon Barnett, midfielderSam Foley and forwardSam Hoskins are among the players pushing for starts.
Cameron Brannagan is finally in contention to make hisOxford debut.
The 21-year-old midfielder joined the U’s from Liverpool in January but suffered an ankle injury in only his second training session.
Caretaker bossDerek Fazackerley confirmed Brannagan was available and also hopes James Henry will shake off a dead leg.
But Joe Rothwell is out for up to three weeks with a hamstring injury.
Watford boss Javi Gracia does not think Abdoulaye Doucoure's form will be affected by his omission from France's latest squad.