Clarke made four changes for Saturday’s 1-1 draw at Oldham and shifted to a 4-5-1 formation.
Rory Gaffney and Chris Lines are among those who could be restored to the Rovers line-up for the Sky Bet League One clash.
But Daniel Leadbitter (hamstring) remains out and James Clarke may not be ready to feature for the first time since the opening day of the season.
In-form Portsmouth will be without Danny Rose and Gareth Evans.
Both men picked up injuries during Saturday’s victory over Northampton, with Rose set to be sidelined for some time after fracturing a leg while Evans was forced off at half-time with a hamstring problem.
Adam May and Jamal Lowe were the men to replace them and both are likely to start against Rovers.
Brandon Haunstrup is also sidelined after sustaining a knee injury in training last week and joins Stuart O’Keefe (adductor), Kal Naismith (knee), Milan Lalkovic (Achilles) and Jack Whatmough (knee).
Rangers manager Steven Gerrard is weighing up a move for Liverpool full-back Jon Flanagan, reports claim.
Scottish champions Celtic are reportedly ready to offer full-back Calvin Miller a new deal before sending him out on loan.
Everton target Jack Wilshere has sparked a scramble for his signature after confirming he is leaving Arsenal this summer.
Tottenham's hopes of landing Wilfried Zaha have been hit by the news Crystal Palace have offered him a bumper new deal to stay.
Ryan Giggs says Gareth Bale would be the perfect fit for Manchester United but has doubts over whether he will leave Real Madrid.
Manchester City's attempts to sign Riyad Mahrez could be in doubt again as reports claim Leicester only want a straight cash deal.