The club announced the 24-year-old, who scored in Saturday’s 1-1 draw with Doncaster, would undergo immediate surgery in a statement on Thursday.
His place in defence could be taken by new signing Zak Vyner, who joined from Bristol City on loan until the end of the season.
Manager Derek Adams is unlikely to make too many other changes as Argyle look to extend their eight-match unbeaten run.
Wigan will have James Vaughan available again for the match.
Vaughan was ineligible for Wednesday’s FA Cup win over Bournemouth but is in contention to play this weekend.
Craig Morgan (hip) and Shaun MacDonald (knee) are both out.
England manager Gareth Southgate has claimed that the country needs to boot racism out of its own football before criticising World Cup hosts Russia.
Newcastle have been linked with a shock move for former Sunderland goalkeeper Simon Mignolet during the summer.