The club announced the 24-year-old, who scored in Saturday’s 1-1 draw with Doncaster, would undergo immediate surgery in a statement on Thursday.
His place in defence could be taken by new signing Zak Vyner, who joined from Bristol City on loan until the end of the season.
Manager Derek Adams is unlikely to make too many other changes as Argyle look to extend their eight-match unbeaten run.
Wigan will have James Vaughan available again for the match.
Vaughan was ineligible for Wednesday’s FA Cup win over Bournemouth but is in contention to play this weekend.
Craig Morgan (hip) and Shaun MacDonald (knee) are both out.
Real Sociedad have firmed up their interest in Newcastle midfielder Mikel Merino by reportedly making an opening offer of £10.5m.
Freiburg defender Caglar Soyuncu says he has turned down offers from Turkish clubs in the hope a move to Arsenal will be finalised.
Watford will reportedly listen to offers for skipper Troy Deeney but will be looking to pick up around £10million for his signature.
Huddersfield are reportedly set to join Tottenham in the race to sign Eintracht Frankfurt's Croatia international star Ante Rebic.