Labadie sat out Friday’s win over Crawley with a stiff hamstring and will be assessed ahead of the midweek fixture.
Fellow midfielder Matty Dolan is also a doubt with a similar problem. Emmanuel Osadebe is in line to make his debut after joining on loan from Cambridge last week.
Morecambe could again be without in-form forward Callum Lang.
The Wigan loanee, who has scored five goals in his last seven games, sat out the weekend defeat to Luton with an ankle injury and faces a late fitness test.
Fellow attacker Vadaine Oliver may return after missing the trip to Kenilworth Road as his partner was due to give birth.
Southampton manager Mark Hughes was delighted to see his new side reach the FA Cup semi-finals but also warned that the Premier League remains a concern.
Borussia Dortmund winger Andre Schurrle was delighted with the team's hard-fought 1-0 Bundesliga victory over Hannover 96 on Sunday afternoon.
Chelsea defender Andreas Christensen has revealed that he sought advice from club legend John Terry after making a few costly mistakes recently.