Pearce collected his fifth yellow card of the season during the 2-2 draw at Bury in midweek and the defender must serve a one-match suspension.
Sam Sodje could be called upon to make his first start of the campaign.
Defender Jude Stirling, midfielders Ishmel Demontagnac, Charlie Allen, on-loan Femi Orenuga and striker Karl Hawley are options for manager Martin Allen should he wish to make changes elsewhere.
Gavin Mahon looks likely to be absent again. The midfielder missed out on Tuesday night with the groin problem that forced him off against Brentford last weekend.
Defender Stephen Hunt (ankle) remains sidelined while goalkeeper Rob Burch has undergone surgery on the knee problem that has blighted his season so far.
A goal apiece from James Tomkins and Luka Milivojevic handed Crystal Palace a crucial 2-0 win over Huddersfield at the John Smith's Stadium on Saturday evening.
Manchester United bounced back from their Champions League exit as they beat Brighton 2-0 at Old Trafford on Saturday night to reach the FA Cup semi-finals.
Tottenham reached the FA Cup semi-finals after they cruised to a 3-0 victory over Swansea in their quarter-final clash at the Liberty Stadium on Saturday.