O’Brien missed last week’s win at Grimsby with injury, but the defender will return to the fray.
Matty Dolan, Joss Labadie and Robbie Willmott all suffered hamstring injuries at Blundell Park but should be fine to play.
New signing Emmanuel Osadebe is unlikely to play after he did not join from Cambridge in time. Crawley have doubts over midfielder Dannie Bulman.
Bulman, who came off during the second half of last weekend’s win over Barnet, is struggling with a knee injury and will be given a late fitness test.
Manager Harry Kewell will definitely be without midfielderJosh Payne as he will complete a three-game ban.
England manager Gareth Southgate has claimed that the country needs to boot racism out of its own football before criticising World Cup hosts Russia.
Newcastle have been linked with a shock move for former Sunderland goalkeeper Simon Mignolet during the summer.