Mills has served a three-match suspension following his straight red card in the 2-0 defeat at Midlands rivals Birmingham.
The club-record signing is likely to go straight back into the starting line-up and resume his central defensive partnership with Sol Bamba, meaning Sean St. Ledger will lose his place in the team.
Leicester are still assessing Darius Vassell and Lloyd Dyer. Dyer replaced Vassell at half-time during the defeat to West Ham on Saturday but then had to be withdrawn himself midway through the second half at Upton Park. Both players are nursing knocks and are doubts.
Academy director Jon Rudkin and coach Mike Stowell will remain in charge for the trip to Turf Moor. Leicester hope to appoint a successor to Sven-Goran Eriksson, who left the club a week ago, before the home game against Leeds on Sunday.