The Reds travel to Fratton Park without their injured skipper after he tore his hamstring in the defeat to Everton and Leiva's red card in the same match means he will also miss out, elsewhere Rafa Benitez, bumps and bruises apart, has a clean bill of health.
Xabi Alonso will be able to play at Pompey but he will then miss next weekend's game against Manchester City after picking up a fifth yellow card against Everton meaning a one match ban.
Meanwhile Dirk Kuyt has called on the players to react in the right way to the defeat on Wednesday when they travel to the South Coast, he told the Post: "We have lost one of our targets but we still have two more to go for because we are still in the Champions League and we are fighting for the Premier League title, so we cannot afford to be too downhearted.
"The key now is how we react to this defeat.
"The positive thing from our point of view is that on the two other occasions we have lost games this season we managed to come back in the weeks that followed.
"That is what we must do now."