The Slovakia defender may not have to face on-loan Anfield team-mate Andy Carroll, who would have been ineligible to play even if he had not been ruled out for two months with a knee injury, but expects a similar test from another big frontman, Carlton Cole.
Cole scored his first goal of the season in the 3-1 win over Chelsea last weekend and Skrtel knows he can be a handful - but that makes it even more enjoyable for the centre-back.
"For me personally it is better if they play with a big striker because that is what I like," Skrtel told Press Association Sport.
"I am more comfortable than playing against smaller guys. But it is no different who is playing, whether it was Andy or Carlton Cole.
"They are all dangerous and we have to focus and be careful for 90 minutes and don't let them score.
"I am looking forward to it and I'll try to do my best to make sure they don't.
"It is going to be a difficult game because it is going to be physical and we have to be ready for that. We have to play our game and try to beat them and I hope the quality is on our side and we can beat them."