The Reds are top of Group E on nine points and need to avoid defeat at Anfield to ensure their place in the last 16 of Europe's elite club competition.
Defeat, coupled with a Sevilla victory over Maribor, would see the Merseysiders drop into the Europa League in the new year.
With that in mind, the German tactician has made it clear his focus is on the Muscovites and not Everton, who they host in the Premier League on Sunday.
"We want to go through and we have the chance to do it," he said. "I don't have to think about the game on Sunday already."
Klopp was without several defenders for last Saturday's 5-1 win at Brighton and Joel Matip is still injured, but Joe Gomez and Ragnar Klavan have recovered from illness and are back in training.
Adam Lallana is still out but Sadio Mane has been tipped to start, while Alberto Moreno is set to return at left-back and Georginio Wijnaldum is expected to revert to a more familiar midfield role after filling in at centre-back on Saturday.