The Manchester City and Belgium midfielder's three assists so far this season have helped put Pep Guardiola's side top of the table, just ahead of rivals United on goal difference.
And the 26-year-old can now claim the bragging rights over Old Trafford legend Cantona when it comes to providing goals for his team-mates.
Frenchman Cantona previously topped the list but De Bruyne, who joined the Citizens from Wolfsburg for a club-record £54m back in 2015, now has a total of 31 assists in 71 games, an average of 0.44 per game.
Cantona had a total of 56 in 156 appearances (0.36 per match) followed by Arsenal's Mesut Ozil (0.35), Chelsea's Cesc Fabregas (0.34) and De Bruyne's City team-mate David Silva (0.31).
De Bruyne also set a Bundesliga record in his final season in Germany, with 21 assists, which saw him named player of the year prior to his big-money move to Manchester.
However, the former Chelsea reject still has a way to go to catch Ryan Giggs as the Welsh winger made 162 total assists during his two decades at the Theatre of Dreams.